The Genetics of Pain
Progress in Pain Research and Management, 
Volume 28

  Jeffrey S. Mogil Editor

Foreword by Ronald Dubner

2004  :  hardbound :  352 pages (approx)  :  
ISBN 0-931092-51-5
US$78.00  (IASP members US$59.00) 

Table of Contents                               Order Form                           IASP         

No field of biology has engendered so much interest, hope, and hype as genetics. Advances in molecular, statistical and behavioral methodologies have suddenly allowed genetic investigations of complex biological phenomena, including pain. Genetic studies of pain are already showing their power to identify new molecular targets for drug development and create new animal models of pain pathology. Alone among biological approaches, pain genetics can explain why we’re not all alike with respect to pain - why some people hurt more, and receive less benefit from existing analgesics. The knowledge gained holds the promise of allowing truly individualized pain therapy.           

Table of Contents

Introduction to Pain Genetics Jeffrey S. Mogil and Marshall Devor


Part I: Genetic Building Blocks of the Pain System

Studies of Pain Mechanisms in Genetically Manipulated Mice. Annika B. Malmberg and Karla P. Zeitz

Identifying Peripheral Mechanisms of Sensory Hyperexcitability by Antisense Oligodeoxynucleotide -

     Mediated Gene Targeting. Josephine Lai and Frank Porreca

Microarray Analysis of the Pain Pathway. Michael Costigan, Robert S. Griffin, and Clifford Woolf

Alternative Splicing of Mu-Opioid Receptors. Gavril W. Pasternak and Ying-Xian Pan


Part II: Pain Susceptibility Genes

Individual Differences in Pain: Rat Models. Xiao-Jun Xu and Zsuzsanna Wiesenfeld-Hallin

Complex Trait Genetics of Pain in the Laboratory Mouse. Jeffrey S. Mogil

The Heritability of Pain in Humans. Alex J. MacGregor

Congenital Insensitivity to Pain. Yasuhiro Indo

Migraine Genetics. Joost Haan, Arn M.J.M. van den Maagdenberg, Aarno Palotie, and Michel D. Ferrari

Pharmacogenetics, Pharmacokinetics, and Analgesia. Jules A. Desmeules, Valerie Piguet,

   Georg B. Ehret, and Pierre Dayer

Pharmacogenetics: The OPRM (Mu-Opioid-Receptor) Gene. Lei Yu


Part III: Complexities, Opportunities, and Worries

Gene-Environment Interactions Affecting Pain Phenotype: Animal Studies. Jeffrey S. Mogil, Ze’ev Seltzer, and Marshall Devor

Social and Environmental Influences on Pain: Implications for Pain Genetics. Roger B. Fillingim

Gene Therapy for Pain. David C. Yeomans and Steven P. Wilson

Ethics and the Genetics of Pain. Margaret A. Somerville

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Page updated: May 26, 2004